Sleep Apnea in Sickle Cell Disease (DREPAPNEE)

  • STATUS
    Recruiting
  • End date
    Apr 28, 2023
  • participants needed
    80
  • sponsor
    Hospices Civils de Lyon
Updated on 1 February 2022
hemoglobin s
blood transfusion
vaso-occlusive crisis
sickle cell trait
sickle hemoglobin

Summary

Despite the fact that obstructive sleep apnoea (OSA) is highly prevalent in the sickle cell population, studies focusing on the associations of the two diseases and their common pathophysiological mechanisms are scarce. OSA is one of the most common conditions responsible for hemoglobin desaturation. The nocturnal hemoglobin desaturation occurring in some sickle cell disease (SCD) patients with OSA could trigger hemoglobin S polymerization and red blood cell (RBC) sickling, leading to further blood rheological alterations, hence increasing the risks for VOC. Moreover, OSA has been demonstrated to increase oxidative stress and inflammation in non Sickle Cell Disease (SCD) patients, which, in SCD patients, could increase the risk for complications. Finally, OSA is accompanied by impaired vascular function and autonomic nervous system dysfunction in the general population. Indeed, the presence of OSA in SCD could increase the clinical severity of patients and the frequency of VOC.

Details
Condition Sickle Cell Disease
Treatment Continuous positive airway pressure, blood samples, physiological measurements, polysomnography and oxygen saturation exam, calculation of VOC rate within the two previous years, calculation of VOC frequency between the first polysomnography and the end of the first year of continuous positive airway pressure treatment
Clinical Study IdentifierNCT03753854
SponsorHospices Civils de Lyon
Last Modified on1 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Homozygous HbS (Hemoglobin S) (SS) patients
aged between 15 and 3 months and 50 years old
in steady state (i.e. without vaso-occlusive crisis or recent blood transfusion)
followed by the sickle cell center of the Hospices Civils de Lyon
and showing symptoms of OSA

Exclusion Criteria

Patients receiving treatment of OSA
recent blood transfusion (less than 2 months)
patients not at steady state (VOC or acute chest syndrome less than 2 months)
pregnancy
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