Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )

  • STATUS
    Recruiting
  • End date
    Jun 30, 2021
  • participants needed
    550
  • sponsor
    Wei-Hai Xu
Updated on 5 April 2020
Investigator
Weihai Xu, MD
Primary Contact
Subei People's Hospital of Jiangsu Province (2.0 mi away) Contact
+37 other location

Summary

A prospective, multicenter, cohort study to explore the stroke mechanisms of symptomatic intracranial atherosclerosis, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus high-resolution magnetic resonance (HR-MRI).

Description

  1. First-ever stroke patients attributed to intracranial artery stenosis (> 50% or occlusion) within 7 days after onset will be prospectively enrolled in our study and undergo new imaging technique package assessment at baseline.
  2. The imaging technique package includes conventional cranial MRI T1,T2,T2 FLAIR,DWI), cranial magnetic resonance angiography (MRA),high-resolution magnetic resonance (HR-MRI) and susceptibility weighted imaging (SWI) or T2*-weighted imaging.
  3. Enrolled patients are recommended to receive aggressive medical management consisted of Aspirin (100 mg daily) and Clopidogrel (75 mg daily) for 3 months and Rosuvastatin (20mg daily) for at least 6 months as well as traditional risk factors management.
  4. Patients were followed up for mRS score, stroke recurrence, medication compliance and laboratory examination including blood routine tests, liver functions and creatine kinase et al at 3 months, 6 months and 12 months after stroke onset. Additionally, patients are required to retake new HRMRI imaging of brain at 6 months.Remote patient education by We-Chat will be performed.
  5. Our study aims to explore the stroke mechanisms of symptomatic intracranial atherosclerosis, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus HR-MRI.

Details
Treatment aggressive medical management
Clinical Study IdentifierNCT03719820
SponsorWei-Hai Xu
Last Modified on5 April 2020

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Eligibility

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Inclusion Criteria

Is your age between 35 yrs and 80 yrs?
Gender: Male or Female
Do you have any of these conditions: Intracranial Atherosclerosis ICAS or Acute Ischemic Stroke AIS?
Age 35-80 years old
First-ever stroke patients confirmed by diffusion weighted imaging (DWI) attributed to intracranial artery stenosis (> 50%) within 7 days after onset
Patients with stable vital signs
Patients who have underwent thrombolytic/intravascular therapy are allowed to enroll in the study

Exclusion Criteria

Patients with > 50% ipsilateral carotid artery stenosis, cardiac embolism ,and any other stroke etiologies such as vasculitis, dissection or other causes
Patients with absolute/relative contraindication to MRI (including but not confined to metal in the body and claustrophobia)
Patients who cannot comply with MRI exam
Patients who decline the consent
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