Last updated on August 2020

M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC)


Brief description of study

The purpose of the study is to evaluate the efficacy and safety of bintrafusp alfa (M7824) compared with pembrolizumab in participants with advanced NSCLC with high PD-L1-tumor expression, with no epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) translocation. The Phase III adaptive design allows for the option to recruit up to 584 patients based on pre-specified rules.

Clinical Study Identifier: NCT03631706

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UC Irvine Medical Center

Orange, CA United States
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UZ Leuven

Pellenberg, Belgium
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Asan Medical Center

Seoul, Korea, Republic of
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Samsung Medical Center

Seoul, Korea, Republic of
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Sansum Clinic - Santa Barbara

Santa Barbara, CA United States
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Woodlands Medical Specialists

Pensacola, FL United States
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Norton Cancer Institute

Louisville, KY United States
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UPMC Cancer Center

Pittsburgh, PA United States
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SCRI - Tennessee Oncology

Nashville, TN United States
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Texas Oncology - Bedford

Bedford, TX United States
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Centro Medico San Roque S.R.L.

San Miguel de Tucuman, Argentina
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Sharp Memorial Hospital (6993)

San Diego, CA United States
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Instituto Medico Especializado Alexander Fleming

Ciudad Autonoma Buenos Aires, Argentina
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Henry Ford Medical Center

Detroit, MI United States
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Cleveland Clinic

Cleveland, OH United States
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Sharp Memorial Hospital

San Diego, CA United States
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Centre L on B rard

Lyon Cedex 08, France
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VU Medisch Centrum

Amsterdam, Netherlands
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Centre L on B rard

Lyon Cedex 08, France
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Recruitment Status: Open


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