OPTImal PALliative Anti-epidermal Growth Factor Receptor Treatment in Metastatic Colorectal Cancer -

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    100
  • sponsor
    Karen-Lise Garm Spindler
Updated on 28 January 2021
growth factor

Summary

The present study will investigate the feasibility and clinical value of using circulating tumor DNA as selection for anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.

Description

The primary aim of this prospective study is to investigate if cfDNA in plasma is feasible and reliable for selection of mCRC patients who will benefit of anti-EGFR monoclonal antibody therapy

Secondary, to analyze developments in mutational status as reflected by cfDNA in plasma during therapy and at time of progression

Details
Condition Metastatic Colorectal Cancer, Colorectal Cancer Metastatic, KRAS Gene Mutation, Circulating Tumor DNA, NRAS Gene Mutation, BRAF Gene Mutation, Epidermal Growth Factor Receptor Inhibitor, egfr inhibitor, egfr blocker
Treatment Plasma circulating DNA analysis
Clinical Study IdentifierNCT03750175
SponsorKaren-Lise Garm Spindler
Last Modified on28 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Histopathologically verified metastatic colorectal cancer
Indication for systemic palliative treatment with standard Anti-EGFR monoclonal antibodies
Fit for therapy with EGFR inhibition
Consent to treatment and sampling
Measureable disease according to RECIST v 1.1
Age 18

Exclusion Criteria

PS > 2
Significant other cancer disease within 5 years of inclusion
Conditions precluding sampling during therapy and treatment breaks
Clear my responses

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