The Effects of Low Carbohydrate Diet on Liver Fat Content and Mitochondrial Fluxes

  • participants needed
  • sponsor
    Helsinki University Central Hospital
Updated on 27 November 2022
Accepts healthy volunteers


The purpose of this study is to examine whether a low carbohydrate diet decreases hepatic lipid content and changes hepatic mitochondrial flux in humans.


In this study, the investigators will examine whether a low carbohydrate diet will change hepatic lipid content and mitochondrial flux in humans. Before and after a low carbohydrate diet intervention, rates of hepatic mitochondrial flux will be assessed using positional isotopomer analysis of 3-13C-lactate during a 3 hour basal period. Rates of whole body ketogenesis will be determined using [13C4]-hydroxybutyrate, and whole body glucose metabolism will be measured using [2H7]glucose. Body composition will be determined with bioelectrical impedance; hepatic lipid content will be measured with MRS. Whole-body oxidation of lipids, carbohydrates and protein will be determined using indirect calorimetry.

Condition Fatty Liver
Treatment Low Carbohydrate Diet
Clinical Study IdentifierNCT03737071
SponsorHelsinki University Central Hospital
Last Modified on27 November 2022

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