Last updated on July 2020

A Study of ABI-H2158 in Healthy Volunteers and Patients With Chronic Hepatitis B

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Hepatitis B | chronic hepatitis b
  • Age: Between 18 - 55 Years
  • Gender: Male or Female

Healthy volunteers:

  1. Male or female between 18 and 55 years old with a BMI of 18-34 kg/m2 with a minimum body weight of 45 kg
  2. Must be in good health and not have any health condition which could interfere with the absorption, distribution or elimination of study drug, or with the clinical and laboratory assessments in this study

Chronic HBV patients:

Key Inclusion Criteria:

  1. Male or female 18 and 65 years of age.
  2. In good general health except for chronic HBV infection, documented by:
  3. Clinical history, physical exam and routine laboratory measurements without major or clinically significant findings
  4. Serologic profile consistent with chronic HBV infection HBeAg-positive at Screening with HBV viral load 2 105 IU/mL
  5. Liver evaluation demonstrating the absence of bridging fibrosis or cirrhosis

Key Exclusion Criteria:

  1. History or evidence of decompensated liver disease at any time prior to Screening
  2. History or presence of any other clinically significant current medical conditions requiring ongoing pharmacological treatment.
  3. Previous treatment with any investigational HBV antiviral treatments within the last 6 months, or previous treatment at any time with an investigational HBV antiviral treatment of the same class (core protein targeted therapies).
  4. Previous treatment with a commercially approved HBV therapy within the last 6 months

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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