Surveillance With PET/CT and Liquid Biopsies of Stage I-III Lung Cancer Patients After Completion of Definitive Therapy

  • STATUS
    Recruiting
  • End date
    Oct 26, 2024
  • participants needed
    750
  • sponsor
    Rigshospitalet, Denmark
Updated on 26 January 2021
ct scan
cancer chemotherapy
liquid biopsy
adjuvant chemotherapy
lung carcinoma

Summary

The purpose of this study is to improve early detection of treatable relapse of lung cancer and thereby improve survival and quality of life for the patients. The investigators will perform a multicenter, randomized controlled trial to 1) assess if surveillance with whole body Positron Emission Tomography combined with Computer Tomography (PET/CT) including the brain can increase the number of treatable relapses and 2) concurrently collect liquid biopsies for later analysis, potentially enabling even earlier and minimally invasive detection and characterization of relapse.

Details
Condition Non-Small Cell Lung Cancer
Treatment Whole body 18F-FDG PET/CT
Clinical Study IdentifierNCT03740126
SponsorRigshospitalet, Denmark
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient with non-small cell lung cancer (NSCLC), proven by cytology or histology
Patient in clinical stages I-III
Age 18 years
Performance status 2 at the time of referral to therapy
Patient referred for definitive treatment (e.g. surgery, surgery followed by adjuvant chemotherapy, concomitant radio-chemotherapy, conventional or stereotactic radiotherapy or radiofrequency ablation)
Patient has given his/her written informed consent before any specific procedure from protocol

Exclusion Criteria

Patient, whose disease has progressed within the first 3 months after cancer treatment, e.g. confirmed progressive disease on CT
Persons deprived of liberty or under guardianship or curators
Dementia, mental alteration, severe psychiatric disease or other circumstances that can compromise informed consent from the patient and/or adherence to the protocol and the monitoring of the trial
Pregnant or breastfeeding women
Patient participating in another interventional study during the surveillance period. This is only relevant for studies that might interfere with the intervention, whereas studies on late effects will not preclude participation in SUPE-R. Participation in protocols related only to initial treatment will not preclude participation in SUPE-R. Cases of doubt will be settled by the steering committee
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