Last updated on November 2018

PeriOperative ISchemic Evaluation-3 Trial

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Venous Thrombosis | Thromboembolism | Arterial Thrombosis | Perioperative Bleeding
  • Age: Between 45 - 100 Years
  • Gender: Male or Female

Inclusion criteria:

  1. Undergoing noncardiac surgery;
  2. 45 years of age;
  3. Expected to require at least an overnight hospital admission after surgery;
  4. Provide written informed consent to participate in the POISE-3 Trial, AND
  5. Fulfill 1 of the following 6 criteria (A-F):
  6. NT-proBNP 200 ng/L B. History of coronary artery disease C. History of peripheral arterial disease D. History of stroke E. Undergoing major vascular surgery; OR F. Any 3 of 9 risk criteria i. Undergoing major surgery; ii. History of congestive heart failure; iii. History of a transient ischemic attack; iv. Diabetes and currently taking an oral hypoglycemic agent or insulin; v. Age >70 years; vi. History of hypertension; vii. Serum creatinine > 175 mol/L (> 2.0 mg/dl); viii. History of smoking within 2 years of surgery; ix. Undergoing emergent/urgent surgery.

Exclusion criteria:

  1. Planned use of systemic TXA during surgery
  2. Hypersensitivity or known allergy to TXA
  3. Creatinine clearance <30 mL/min (Modification of Diet in Renal Disease [MDRD])
  4. History of seizure disorder
  5. Patients with recent stroke, myocardial infarction, acute arterial thrombosis or venous thromboembolism (<1 month)
  6. Patients with subarachnoid hemorrhage within the past 30 days
  7. Patients undergoing cranial neurosurgery
  8. Previously enrolled in POISE-3 Trial

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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