Last updated on November 2018

PeriOperative ISchemic Evaluation-3 Trial


Brief description of study

This study is a multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy.

Detailed Study Description

The POISE-3 study is a 10,000 patient, multicentre, international, non-inferiority randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy. The primary objective of the study is to determine; if TXA is superior to placebo for the occurrence of life-threatening, major, and critical organ bleeding, and non-inferior to placebo for the occurrence of major arterial and venous thrombotic event; and to determine the impact of a hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of vascular death and major vascular events in patients who are followed for 30 days after noncardiac surgery.

Clinical Study Identifier: NCT03505723

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Columbia University

New York, NY United States
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Wake Forest

Winston-Salem, NC United States
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Cleveland Clinic - Fairview

Cleveland, OH United States
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Cleveland Clinic - Main Campus

Cleveland, OH United States
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Cleveland Clinic - Hillcrest

Mayfield Heights, OH United States
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MD Anderson Cancer Center

Houston, TX United States
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Flinders Medical Centre

Bedford Park, Australia
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Dandenong Hospital

Dandenong, Australia
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Austin Hospital

Heidelberg, Australia
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CHU Brugmann

Brussels, Belgium
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Vera Cruz Hospital

Belo Horizonte, Brazil
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Hospital Barra D'Or

Rio De Janeiro, Brazil
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Grace Hospital

Winnipeg, MB Canada
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CHUM

Montreal, QC Canada
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Sherbrooke

Sherbrooke, QC Canada
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Sevenhills Hospital

Visakhapatnam, India
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PO Busto Arsizio

Busto Arsizio, Italy
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Pineta Grande Hospital

Castel Volturno, Italy
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Port Dickson Hospital

Port Dickson, Malaysia
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Hospital Pulau Pinang

Pulau Pinang, Malaysia
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Deventer Ziekenhuis

Deventer, Netherlands
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Recruitment Status: Open


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