Last updated on January 2020

GB001 in Adult Subjects With Moderate to Severe Asthma

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Asthma (Pediatric) | Allergies & Asthma | Asthma
  • Age: Between 18 - 74 Years
  • Gender: Male or Female

Inclusion Criteria

  • A diagnosis of asthma by a physician at least 12 months before Screening Visit.
  • Treated with medium or high dose inhaled corticosteroid (ICS) plus additional controller for at least 12 months prior to Screening Visit. Subjects must maintain a stable ICS dose regimen during the 4 weeks prior to the Screening Visit.
  • FEV1 of 85% of predicted normal
  • Demonstrated reversibility of at least 12% in FEV1
  • Evidence of uncontrolled asthma
  • Eosinophilic asthma
  • No changes in ICS dose and compliant with SOC asthma therapy during run-in period.

Exclusion Criteria

  • Current smokers (any substance)
  • QTcF (Fridericia) 450 msec (male) or 470 msec (female)
  • Use of other investigational drugs within 30 days, or within 5 half-lives, whichever is longer, prior to Screening Visit
  • Pregnant or breastfeeding
  • Serious co-morbidities
  • Regular use of systemic corticosteroids or immunosuppressive treatments or monoclonal antibodies for asthma

Other protocol-defined inclusion/exclusion criteria may apply

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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