Last updated on August 2019

A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia


Brief description of study

This study is designed to compare the overall response rate of zanubrutinib versus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

Detailed Study Description

This is a global, Phase 3, randomized study of zanubrutinib versus ibrutinib in approximately 400 patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

The primary efficacy endpoint is overall response rate determined by independent central review. Patients will be randomized in a 1:1 manner to either zanubrutinib or ibrutinib. Treatment with zanubrutinib and ibrutinib will be open label.

Clinical Study Identifier: NCT03734016

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Summit Medical Group

Florham Park, NJ United States
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Clinical Research Alliance Inc

Lake Success, NY United States
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Medical Oncology Associates

Spokane, WA United States
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Adelaide Cancer Centre

Kurralta Park, Australia
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Wellington Hospital

Newtown, New Zealand
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Tauranga Hospital

Tauranga, New Zealand
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Kent and Canterbury Hospital

Canterbury, United Kingdom
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CARTI Cancer Center

Little Rock, AR United States
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Augusta University

Augusta, GA United States
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Central Care Cancer Center

Bolivar, MO United States
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SCRI HCA Midwest Health

Kansas City, MO United States
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Atlantic Health System

Morristown, NJ United States
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Leo W. Jenkins Cancer Center

Greenville, NC United States
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Texas Oncology (Loop) - USOR

Fort Worth, TX United States
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MD Anderson Cancer Center

Houston, TX United States
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Box Hill Hospital

Box Hill, Australia
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Gelre Ziekenhuizen

Apeldoorn, Netherlands
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Martini Ziekenhuis

Groningen, Netherlands
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North Shore Hospital

Takapuna, New Zealand
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Middlemore Hospital

Auckland, New Zealand
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Waikato Hospital

Hamilton, New Zealand
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Hopital Prive Sevigne

Cesson-Sévigné, France
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SCRI Florida Cancer Specialists North

Saint Petersburg, FL United States
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Hopital Prive Sevigne

Cesson-Sévigné, France
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Hopital Prive Sevigne

Cesson-Sévigné, France
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