A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia

  • STATUS
    Recruiting
  • End date
    Aug 1, 2022
  • participants needed
    600
  • sponsor
    BeiGene
Updated on 5 May 2021
lymphoid leukemia
chronic lymphocytic leukemia
lymphoma
measurable disease
ibrutinib
chronic lymphocytic leukemia refractory

Summary

This study is designed to compare the overall response rate of zanubrutinib versus ibrutinib in participants with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

Description

This is a global, Phase 3, randomized study of zanubrutinib versus ibrutinib in approximately 600 participants with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

The primary efficacy endpoint is overall response rate determined by investigator assessment. Participants will be randomized in a 1:1 manner to either zanubrutinib or ibrutinib. Treatment with zanubrutinib and ibrutinib will be open label.

Details
Condition Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Chronic, leukemia chronic lymphocytic, chronic lymphocytic leukemia (cll), small lymphocytic lymphoma, b-cell small lymphocytic lymphoma
Treatment Ibrutinib, BGB-3111, Zanubrutinib
Clinical Study IdentifierNCT03734016
SponsorBeiGene
Last Modified on5 May 2021

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