Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer. (SERENA-1)

  • STATUS
    Recruiting
  • End date
    Oct 16, 2023
  • participants needed
    305
  • sponsor
    AstraZeneca
Updated on 24 July 2022

Summary

A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination in Women with ER Positive, HER2 Negative Advanced Breast Cancer (SERENA-1)

Description

This is a multicentre dose escalation and expansion, first-in-human study designed to evaluate the safety and tolerability of AZD9833, alone (Parts A and B) or in combination with palbociclib (Parts C and D) or in combination with everolimus (Parts E and F) or in combination with abemaciclib (Parts G and H) or in combination with capivasertib (Parts I and J), in women with endocrine-resistant ER+ HER2- breast cancer that is not amenable to treatment with curative intent.

Details
Condition ER+ HER2- Advanced Breast Cancer
Treatment AZD9833, AZD9833 with palbociclib, AZD9833 with everolimus, AZD9833 with abemaciclib dose escalation, AZD9833 with abemaciclib, AZD9833 with capivasertib
Clinical Study IdentifierNCT03616587
SponsorAstraZeneca
Last Modified on24 July 2022

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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