Last updated on November 2018

Systemic Probiotics in the Periodontal Treatment


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Periodontitis
  • Age: Between 30 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • 30 years of age;
  • at least 15 teeth (excluding third molars and teeth with advanced decay indicated for extraction);
  • a minimum of 6 teeth with at least one site each with probing depth (PD) and clinical attachment level (CAL) 5 mm;
  • at least 30% of the sites with probing depth (PD) and clinical attachment level (CAL) 4 mm and bleeding on probing (BOP);

Exclusion Criteria:

  • pregnancy;
  • breastfeeding;
  • current smoking and former smoking within the past 5 years;
  • systemic diseases that could affect the progression of periodontitis (e.g. diabetes, immunological disorders, osteoporosis);
  • scaling and root planing an in the previous 12 months;
  • antibiotic therapy in the previous 6 months;
  • long-term intake of anti-inflammatory medications;
  • need for antibiotic pre-medication for routine dental therapy;
  • use of orthodontic appliances;
  • extensive dental prosthetic rehabilitation;
  • allergy to metronidazole and/or amoxicillin.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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