Comparison of Minimal Invasive Lens Surgery and Traditional Cataract Surgery

  • End date
    Dec 24, 2022
  • participants needed
  • sponsor
    Sun Yat-sen University
Updated on 24 May 2022


Previously, we have developed a minimal invasive lens surgery in the purpose of reduce post-operative complications of congenital cataract. This prospective, randomized controlled study aims at comparing the prognosis of the minimal invasive lens surgery and the traditional cataract surgery for treating congenital cataracts.


Patients with congenital cataract that requires surgical intervention are enrolled. Then the patients are assigned to two groups: Group I: the participants receive a minimal invasive lens surgery, while in Group II, the participants receive a traditional cataract surgery. A secondary intraocular lens implantation is performed when the patient is two years old for both Group I and Group II. Investigators then compare the visual acuity, incidence of high intraocular pressure, incidence of visual axis opacification, uveitis and iris/pupil abnormality between two groups, to evaluate and compare the prognosis of minimal invasive lens surgery and traditional cataract surgery for treating congenital cataracts.

Condition Congenital Cataract
Treatment minimal invasive lens surgery, traditional cataract surgery
Clinical Study IdentifierNCT03230799
SponsorSun Yat-sen University
Last Modified on24 May 2022


Yes No Not Sure

Inclusion Criteria

Age between 1 month and 24 months
Uncomplicated congenital cataract (≥ 3 mm central dense opacity) in one or both eyes with an intact non-fibrotic capsular bag
Informed consent signed by a parent or legal guardian

Exclusion Criteria

confirmed or suspected hereditary cataract, including and not restricted to family history of congenital cataract
Intraocular pressure >21 mmHg
Preterm birth (<28 weeks)
Presence of other ocular diseases (keratitis, keratoleukoma, aniridia, glaucoma) or systemic disease (congenital heart disease, ischemic encephalopathy)
History of ocular diseases (any congenital eye diseases, such as, congenital cataract, congenital glaucoma, congenital aniridia) in the family
History of ocular trauma
Persistent hyperplastic primary vitreous
Lowe syndrome
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