TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck
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- STATUS
- Recruiting
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- End date
- Oct 11, 2024
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- participants needed
- 150
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- sponsor
- Abramson Cancer Center of the University of Pennsylvania
Summary
This is a single-arm Phase II study of adjuvant radiation for locally advanced p16+ oropharyngeal squamous cell carcinoma. The main purpose of this research is to determine the likelihood of cancer growing back in the throat or in the neck two years after completion of radiation if lower doses of radiation are used to a smaller area of the head and neck region than is currently used in standard of care.
Description
This is a single arm Phase II study of adjuvant radiation for locally-advanced p16+ oropharyngeal squamous cell carcinoma. Patients with pT0-T3, N0-N2b, M0 disease (per AJCC 7th ed) with <5 positive lymph nodes, will be eligible. Patients will have undergone TORS primary site resection and ipsilateral neck dissection. Patients will undergo radiation dose reduction and target volume reduction.
Details
| Condition | Oropharyngeal Cancer, Squamous Cell Carcinoma, Human Papilloma Virus |
|---|---|
| Treatment | Radiation Therapy (IMRT or IMPT) |
| Clinical Study Identifier | NCT03729518 |
| Sponsor | Abramson Cancer Center of the University of Pennsylvania |
| Last Modified on | 18 December 2021 |
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