BFR and Muscle Mitochondrial Oxidative Capacity

  • End date
    Aug 31, 2023
  • participants needed
  • sponsor
    Louisiana State University and A&M College
Updated on 12 August 2022
body mass index
dual energy x-ray absorptiometry
resistance training
near infrared spectroscopy
x-ray absorptiometry
Accepts healthy volunteers


Blood flow restricted (BFR) exercise has been shown to improve skeletal muscle adaptations to resistance exercise. BFR uses blood pressure cuffs (i.e., tourniquets) to reduce skeletal muscle blood flow during resistance exercise. One benefit of BFR is that skeletal muscle adaptations to resistance exercise training including muscle hypertrophy and increases in strength can be achieved at lower-loads (e.g., 25-30% 1RM), that are often comparable to more traditional resistance training loads (70-85% 1RM). However, the impact that low-load BFR resistance exercise has on muscle quality and bioenergetics is unknown. The present study will examine the impact of 6 weeks of low-load, single-leg resistance exercise training with or without personalized BFR on measures of muscle mass, strength, quality, and mitochondrial bioenergetics. The investigators will recruit and study up to 30, previously sedentary, healthy, college-aged adults (18-40 years). The investigators will measure muscle mass using Dual Energy X-Ray Absorptiometry and muscle strength and endurance using isokinetic testing. The investigators will normalize knee extensor strength to lower limb lean mass to quantify muscle quality. The investigators will also use near infrared spectroscopy (NIRS) to measure mitochondrial oxidative capacity in the vastus lateralis. Finally, the investigators will measure markers of systemic inflammation and markers of muscle damage using commercially available ELISA assays.

Condition Mitochondria, Strength, Hypertrophy
Treatment Low Load Resistance Exercise, Low Load Resistance Exercise + BFR
Clinical Study IdentifierNCT03723226
SponsorLouisiana State University and A&M College
Last Modified on12 August 2022


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