• End date
    Jun 30, 2024
  • participants needed
  • sponsor
    Harvard Pilgrim Health Care
Updated on 9 September 2021
antibiotic therapy
critical illness


The INSPIRE-ASP PNA trial is a cluster-randomized controlled trial of HCA hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts providing the probability that a non-critically ill adult admitted with PNA is infected with a resistant pathogen.

Note: that enrolled "subjects" represents 59 individual HCA hospitals that have been randomized.

Condition Pulmonary Disease, Upper respiratory infection, Pneumonia, Throat and Tonsil Infections, Pneumonia (Pediatric), Lung Disease, pneumoniae, pneumonitis, lung inflammation
Treatment Routine care, INSPIRE CPOE Smart Prompt
Clinical Study IdentifierNCT03697070
SponsorHarvard Pilgrim Health Care
Last Modified on9 September 2021


Yes No Not Sure

Inclusion Criteria

HCA hospitals admitting adults with PNA
Facility use of MEDITECH as their electronic health record system

Exclusion Criteria

Note: unit of randomization is the hospital, however the CPOE alert
intervention will calculate risk estimates for adults age >=18 admitted to
non-ICU wards and who are ordered to receive extended-spectrum antibiotics for
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Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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