Exercise for Brain Health in the Fight Against Alzheimer's Disease

  • End date
    Apr 11, 2023
  • participants needed
  • sponsor
    University of Maryland, College Park
Updated on 11 November 2020


The investigators aim to compare the effects of a 6-month moderate intensity exercise training (ET) intervention to a low intensity flexibility exercise control condition (FC) on brain function, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80). Apolipoprotein E epsilon4 (APOE-4) allele carriers are known to be at substantially greater risk for cognitive decline and Alzheimer's disease (AD). Cognitively intact APOE-4 allele carriers, and non-carriers, will be randomly assigned to 6-months of either supervised moderate intensity aerobic exercise training (ET) or supervised flexibility exercise control (FC). The ET and FC each contain a group based exercise component and are run in local retirement communities near College Park, MD, or on the University of Maryland College Park campus. The primary aims of the study are to compare pre-intervention to post-intervention changes in episodic memory performance and MRI biomarkers.

Treatment exercise training, Flexibility Control
Clinical Study IdentifierNCT03727360
SponsorUniversity of Maryland, College Park
Last Modified on11 November 2020

Adding a note
adding personal notes guide

Select a piece of text and start making personal notes.


Yes No Not Sure

Inclusion Criteria

Is your age between 60 yrs and 80 yrs?
Gender: Male or Female
Do you have Healthy Cognition?
Do you have any of these conditions: Do you have Healthy Cognition??
to 80 years old
Fluent in English
Willingness to make the time commitment to participate in the project, including randomization to treatments
Physically inactive (physical activity not more than 2 days per week for the past 6 months)
Physician consent to undergo an exercise stress test and engage in moderate intensity exercise
Determined to be safe for MRI

Exclusion Criteria

Neurological illnesses/conditions such as cerebral palsy, epilepsy, brain tumor, chronic meningitis, multiple sclerosis, pernicious anemia, normal-pressure hydrocephalus, HIV infection, Parkinson's disease, and Huntington's disease
Untreated hypertension, glaucoma, and chronic obstructive pulmonary disease
Untreated severe major depression
Substance abuse or dependence
Current use of psychoactive medications, except selective serotonin/norepinephrine reuptake inhibitor antidepressants
Use of acetylcholinesterase inhibitors (e.g., Aricept)
Unstable or severe cardiovascular disease or asthmatic condition
History of transient ischemic attack, cerebral ischemia, or clinically diagnosed stroke
Diagnosis of mild cognitive impairment or dementia, or objective evidence of cognitive impairment
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Phone Email

Please verify that you are not a bot.
Step 2 Get screened

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more
Step 3 Enroll in the clinical study

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more
Step 4 Get your study results

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer


user name

Annotated by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No made yet