Exercise for Brain Health in the Fight Against Alzheimer's Disease

  • days left to enroll
  • participants needed
  • sponsor
    University of Maryland, College Park
Updated on 16 February 2022
Accepts healthy volunteers


The investigators aim to compare the effects of a 6-month moderate intensity exercise training (ET) intervention to a low intensity flexibility exercise control condition (FC) on brain function, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80). Apolipoprotein E epsilon4 (APOE-4) allele carriers are known to be at substantially greater risk for cognitive decline and Alzheimer's disease (AD). Cognitively intact APOE-4 allele carriers, and non-carriers, will be randomly assigned to 6-months of either supervised moderate intensity aerobic exercise training (ET) or supervised flexibility exercise control (FC). The ET and FC each contain a group based exercise component and are run in local retirement communities near College Park, MD, or on the University of Maryland College Park campus. The primary aims of the study are to compare pre-intervention to post-intervention changes in episodic memory performance and MRI biomarkers.

Condition Healthy Cognition
Treatment exercise training, Flexibility Control
Clinical Study IdentifierNCT03727360
SponsorUniversity of Maryland, College Park
Last Modified on16 February 2022


Yes No Not Sure

Inclusion Criteria

to 80 years old
Fluent in English
Willingness to make the time commitment to participate in the project, including randomization to treatments
Physically inactive (physical activity not more than 2 days per week for the past 6 months)
Physician consent to undergo an exercise stress test and engage in moderate intensity exercise
Determined to be safe for MRI

Exclusion Criteria

Neurological illnesses/conditions such as cerebral palsy, epilepsy, brain tumor, chronic meningitis, multiple sclerosis, pernicious anemia, normal-pressure hydrocephalus, HIV infection, Parkinson's disease, and Huntington's disease
Untreated hypertension, glaucoma, and chronic obstructive pulmonary disease
Untreated severe major depression
Substance abuse or dependence
Current use of psychoactive medications, except selective serotonin/norepinephrine reuptake inhibitor antidepressants
Use of acetylcholinesterase inhibitors (e.g., Aricept)
Unstable or severe cardiovascular disease or asthmatic condition
History of transient ischemic attack, cerebral ischemia, or clinically diagnosed stroke
Diagnosis of mild cognitive impairment or dementia, or objective evidence of cognitive impairment
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