Serum Biomarkers for Portal Hypertension in Cirrhosis (Pan-CHESS1802)

  • STATUS
    Recruiting
  • participants needed
    75
  • sponsor
    Nanfang Hospital of Southern Medical University
Updated on 27 June 2022
venous pressure
cirrhosis
hepatic venous pressure gradient

Summary

This is a prospective, multi-center diagnostic trial conducted at 6 liver centers in China designed to study the correlation between serum biomarkers associated with endothelial dysfunction and immune inflammation and hepatic venous pressure gradient in cirrhosis.

Description

Hepatic venous pressure gradient (HVPG) is the gold standard for assessing portal pressure, of which the measurement is invasive and therefore not suitable for routine clinical practice. The detection of serum biomarkers is potential for noninvasive diagnosis of portal hypertension in cirrhosis. However, many are still in the exploratory phases of testing and are not yet ready to enter clinical practice. This study prospectively enrolled participants in 6 liver centers (Beijing YouAn Hospital, Shandong Provincial Hospital, Beijing Shijitan Hospital, Beijing Friendship Hospital, Xingtai People's Hospital, and 302 Hospital of PLA) in China designed to study the correlation between serum biomarkers associated with endothelial dysfunction and immune inflammation and HVPG in cirrhosis.

Details
Condition Hypertension, Portal
Treatment HVPG measurement
Clinical Study IdentifierNCT03713606
SponsorNanfang Hospital of Southern Medical University
Last Modified on27 June 2022

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