Mechanisms of Change in Brief Treatment for Borderline Personality Disorder (BPDCHANGE)

  • End date
    Dec 22, 2022
  • participants needed
  • sponsor
    University of Lausanne Hospitals
Updated on 15 February 2022


The present two-arm randomized controlled study aims at testing the effects (i.e., symptom reduction) and the underlying mechanisms of change associated with a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants undergo assessments at four points (intake, 2 months, discharge and 12 month follow-up). In addition to symptom measures, all individuals undergo a two-step assessment for the potential mechanisms of change (i.e., emotion and socio-cognitive processing): a) behavioural and b) neurofunctional. We hypothesize that change in the mechanisms explains the treatment effects. The present study uses an innovative treatment of BPD and at the same time a sophisticated assessment procedure to demonstrate the critical role of psychobiological change in emotion and sociocognitive processing in brief treatments. It will help increase the effectiveness of initial treatment phase for BPD and help diminish the societal burden of disease related with BPD. This study is funded by the Swiss National Science Foundation (SNSF).

Condition Borderline Personality Disorder
Treatment Treatment As Usual, Good Psychiatric Management - Brief
Clinical Study IdentifierNCT03717818
SponsorUniversity of Lausanne Hospitals
Last Modified on15 February 2022


Yes No Not Sure

Inclusion Criteria

Borderline Personality Disorder
age between 18 and 35

Exclusion Criteria

non-mastery in French
neurological disorders
schizophrenia (according to DSM-5)
Clear my responses

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