Acetazolamide in Patients With Acute Heart Failure

    Not Recruiting
  • participants needed
  • sponsor
    University of Sao Paulo General Hospital
Updated on 22 January 2021
acute heart failure
b-type natriuretic peptide
diuretic therapy
decompensated heart failure


Introduction: Recent studies have suggested that the use of acetazolamide may assist in the vol- ume management of patients with decompensated heart failure (HF). However, prospective and randomized comparison in patients with HF and optimized diuretic therapy has not been described. Objective: The aim of this study was to evaluate the effectiveness and safety of the use of acetazolamide versus placebo in volume control in patients with decompensated HF. Methodology: For this, a unicentric, randomized, double blind and prospective study will be performed in a comparative manner. Hospital data (test results, medical outcomes, drug dose, complications) of patients will be analyzed for safety and effectiveness. Expected results: The use of acetazolamide as an adjuvant treatment is superior to the standard strategy for volume control in patients with decompensated HF.

Condition Heart failure, Acute Heart Failure
Treatment Placebo, acetazolamide
Clinical Study IdentifierNCT03720288
SponsorUniversity of Sao Paulo General Hospital
Last Modified on22 January 2021

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