Last updated on October 2018

Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer


Brief description of study

The aim of this RCT is to compare differences in the efficacy and safety between cleavage-stage embryo transfer and blastocyst-stage embryo transfer in IVF/ICSI treatment cycle, taking into account of subsequent vitrified embryo transfers. Subjects with 4 or more transferrable cleavage embryos will be randomized to the cleavage-stage or blastocyst-stage embryos transfer group. The primary outcome is cumulative live birth rate (CLBR) per patient until the first live birth from one initiated oocyte retrieval cycle.

Detailed Study Description

This is a multicenter, randomized clinical trial comparing the efficacy and safety between cleavage-stage embryo transfer and blastocyst-stage embryo transfer in IVF/ICSI treatment cycle, taking into account of subsequent vitrified embryo transfers.Randomization will be performed on day 2/3 after oocyte retrieval, when at least 4 embryos are achieved. Patients in group A will have 1 cleavage-stage embryo transferred. Patients in group B will have 1 blastocyst-stage embryo transferred. Each patient will be followed up until the first live birth is achieved or until all the embryos per oocyte retrieval are transferred (up to 5 single embryo transfers), including fresh and frozen-thawed embryo transfers. If a live birth is not achieved, single embryo transfers will be consecutively performed 5 times at most within 1.5 years follow-up duration. The follow-up period is 2.5 years from the day of randomization.

Clinical Study Identifier: NCT03152643

Contact Investigators or Research Sites near you

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Junli Zhao

General Hospital of Ningxia Medical University
Yinchuan, China
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Recruitment Status: Open


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