Last updated on May 2019

Effects of Pneumatic Vitreolysis on Vitreomacular Traction

Brief description of study

Eyes with idiopathic symptomatic vitreomacular traction (VMT) without a macular hole will be randomly assigned to 0.3-mL intraocular gas (C3F8) injection or sham injection to determine if pneumatic vitreolysis (PVL) is effective in releasing VMT.

Detailed Study Description

Investigational Device: 0.3-mL intraocular gas (C3F8) injection



  1. To compare the proportion of eyes with foveal VMT release on OCT after pneumatic vitreolysis with gas injection versus observation (sham injection) in eyes with VMT without an associated macular hole.


2. To evaluate visual function outcomes at 24 weeks after gas injection is performed compared with sham injection.

Study Design: Multi-center, randomized clinical trial

Clinical Study Identifier: NCT03647267

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Sarasota Retina Institute

Sarasota, FL United States
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Raj K. Maturi, M.D., P.C.

Indianapolis, IN United States
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Retinal Diagnostic Center

Campbell, CA United States
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Atlantis Eye Care

Huntington Beach, CA United States
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Florida Retina Institute

Orlando, FL United States
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Southeast Retina Center, PC

Augusta, GA United States
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Thomas Eye Group

Sandy Springs, GA United States
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Gailey Eye Clinic

Bloomington, IL United States
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Wolfe Eye Clinic

West Des Moines, IA United States
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Mid-America Retina Consultants, P.A.

Overland Park, KS United States
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Paducah Retinal Center

Paducah, KY United States
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Elman Retina Group, PA

Baltimore, MD United States
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Joslin Diabetes Center

Boston, MA United States
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Vitreo-Retinal Associates, PC

Worcester, MA United States
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Retina Specialists of Michigan

Grand Rapids, MI United States
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The Retina Institute

Saint Louis, MO United States
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Retina Northwest, PC

Portland, OR United States
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Southeastern Retina Associates

Chattanooga, TN United States
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Austin Retina Associates

Austin, TX United States
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Retina Research Center

Austin, TX United States
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Spokane Eye Clinic

Spokane, WA United States
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Florida Retina Consultants

Lakeland, FL United States
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Retina Vitreous Center

Edmond, OK United States
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Oregon Retina, LLP

Eugene, OR United States
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Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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