Biological Dating of Cerebral Ischemia With GST- /PRDX1 to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis

  • STATUS
    Recruiting
  • End date
    Jan 1, 2022
  • participants needed
    945
  • sponsor
    Central Hospital, Nancy, France
Updated on 28 January 2021
infarct
ischemia
cerebral infarction

Summary

The FLAG1 study will assess the diagnostic performance of biomarkers Glutathion S-Transferase- (GST-) and Peroxyredoxin 1 (PRDX1) to identify cerebral infarction of less than 4,5 hours in a population of patients with neurological deficiency of less than 12 hours.

Details
Condition Cerebrovascular accident, Stroke, acute stroke
Treatment blood samples
Clinical Study IdentifierNCT03364296
SponsorCentral Hospital, Nancy, France
Last Modified on28 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients over 18 years old
Patients with symptoms consistent with stroke and a National Institute of Health Stroke Score 3 at the inclusion time
Time symptom onset 12 hours at inclusion
For patients with time of symptom onset is <4.5h at inclusion, the time of symptom onset has to be precisely known, with a margin of error not exceeding 30 minutes (through patient or witness interview)
Possibility to perform MRI within the 30 minutes following blood collection
For patients with time of symptom onset is >4.5h at inclusion, knowledge of precise time of symptom onset is not required. For these patients, to ensure onset-to-inclusion time is between 4.5 and 12 hours at inclusion
Person affiliated to or beneficiary of a social security plan
last time patient presented no deficit must be less than 12 hours
symptoms must have been first recognized more than 4.5 hours before blood draw

Exclusion Criteria

Persons referred in articles L.1121-5, L.1121-7, L.1121-8 and L.1122-2 of the French Public Health Code: Pregnant, parturient or breastfeeding woman ; Minor person (non-emancipated) ; Adult person under legal protection (any form of public guardianship) ; Adult person incapable of giving consent and not under legal protection
Persons deprived of liberty for judicial or administrative decision
Persons subject to psychiatric care under articles L.3212-1 and L.3213-1 of the French Public Health Code
Known cancer in progression
Known cirrhosis
Myocardial Infarctions, stroke, Subarachnoid hemorrhage or intracranial injury within 3 months prior to enrolment
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

0/250
Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note