Biological Dating of Cerebral Ischemia With GST- /PRDX1 to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis

  • End date
    Jan 1, 2022
  • participants needed
  • sponsor
    Central Hospital, Nancy, France
Updated on 28 January 2021
cerebral infarction


The FLAG1 study will assess the diagnostic performance of biomarkers Glutathion S-Transferase- (GST-) and Peroxyredoxin 1 (PRDX1) to identify cerebral infarction of less than 4,5 hours in a population of patients with neurological deficiency of less than 12 hours.

Condition Cerebrovascular accident, Stroke, acute stroke
Treatment blood samples
Clinical Study IdentifierNCT03364296
SponsorCentral Hospital, Nancy, France
Last Modified on28 January 2021


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Inclusion Criteria

Patients over 18 years old
Patients with symptoms consistent with stroke and a National Institute of Health Stroke Score 3 at the inclusion time
Time symptom onset 12 hours at inclusion
For patients with time of symptom onset is <4.5h at inclusion, the time of symptom onset has to be precisely known, with a margin of error not exceeding 30 minutes (through patient or witness interview)
Possibility to perform MRI within the 30 minutes following blood collection
For patients with time of symptom onset is >4.5h at inclusion, knowledge of precise time of symptom onset is not required. For these patients, to ensure onset-to-inclusion time is between 4.5 and 12 hours at inclusion
Person affiliated to or beneficiary of a social security plan
last time patient presented no deficit must be less than 12 hours
symptoms must have been first recognized more than 4.5 hours before blood draw

Exclusion Criteria

Persons referred in articles L.1121-5, L.1121-7, L.1121-8 and L.1122-2 of the French Public Health Code: Pregnant, parturient or breastfeeding woman ; Minor person (non-emancipated) ; Adult person under legal protection (any form of public guardianship) ; Adult person incapable of giving consent and not under legal protection
Persons deprived of liberty for judicial or administrative decision
Persons subject to psychiatric care under articles L.3212-1 and L.3213-1 of the French Public Health Code
Known cancer in progression
Known cirrhosis
Myocardial Infarctions, stroke, Subarachnoid hemorrhage or intracranial injury within 3 months prior to enrolment
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