Last updated on October 2018

Eplerenone as a Supplement to Epidural Steroid Injections


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Sciatic Radiculopathy | Low Back Pain | Degenerative Intervertebral Discs
  • Age: Between 18 - 65 Years
  • Gender: Male or Female

Inclusion Criteria:

  • diagnosis of lumbar degenerative disc disease demonstrated on either lumbar X-Ray or lumbar MRI.
  • unilateral radicular symptoms or electromyograph consistent with radiculopathy and exam findings corresponding to this diagnosis: with symptoms reflecting a dermatomal distribution of pain and positive response to straight leg raise test
  • Scheduled for lumbar epidural steroid injection as part of routine clinical care
  • Negative pregnancy test, if of childbearing potential

Exclusion Criteria:

  • Unable to complete questionnaires or give informed consent in English
  • Unavailable for follow-up contacts to complete questionnaires
  • Renal impairment (estimated glomerular filtration rate <50 mL/min or serum creatinine >1.8mg/dL) on metabolic panel obtained just prior to epidural injections.
  • Elevated serum potassium (>5.5 milliequivalents/L) on metabolic panel obtained just prior to epidural injections.
  • Have undergone previous lumbar surgery.
  • Treated with oral steroids or injectable steroid within the past year.
  • Diabetic
  • Systolic blood pressure reading less than 100 mm Hg at most recent clinic visit.
  • Prescribed protease inhibitors.
  • Taking strong CYP3A4 inhibitors
  • Taking potassium supplements or potassium-sparing diuretics (amiloride, spironolactone, or triamterene) or using salt substitutes that contain potassium (examples given below and in the prescreening document to be used by the study nurse).
  • Lactating.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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