Last updated on May 2019

Effects of Pneumatic Vitreolysis on Macular Hole


Brief description of study

Eyes with vitreomacular traction (VMT) and full-thickness macular holes (MH) will be enrolled into a non-randomized cohort treated with pneumatic vitreolysis (PVL) to determine the proportion with VMT release and MH closure and to assess factors associated with success.

Detailed Study Description

The objective of this trial is to obtain estimates of the proportion of eyes with MH closure of the inner retinal layers for eyes with VMT and full-thickness MHs treated with PVL. Understanding the rates of VMT release and MH closures in eyes with full-thickness MH treated with PVL is of interest. Surgery would result in nearly 100% hole closure and VMT release, making vitrectomy a poor control group choice. Spontaneous resolution of MH is highly unlikely, making an observation arm unnecessary. Therefore, these eyes will be enrolled into a non-randomized cohort treated with PVL to assess the outcomes of treatment.

Clinical Study Identifier: NCT03677869

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Retinal Diagnostic Center

Campbell, CA United States
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Atlantis Eye Care

Huntington Beach, CA United States
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Florida Retina Institute

Orlando, FL United States
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Sarasota Retina Institute

Sarasota, FL United States
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Southeast Retina Center, PC

Augusta, GA United States
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Thomas Eye Group

Sandy Springs, GA United States
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Gailey Eye Clinic

Bloomington, IL United States
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Carle Foundation Hospital

Urbana, IL United States
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Raj K. Maturi, MD, PC

Indianapolis, IN United States
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Wolfe Eye Clinic

West Des Moines, IA United States
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Mid-America Retina Consultants, P.A.

Overland Park, KS United States
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Paducah Retinal Center

Paducah, KY United States
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Elman Retina Group, BA

Baltimore, MD United States
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Joslin Diabetes Center

Boston, MA United States
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Vitreo-Retinal Associates, PC

Worcester, MA United States
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Retina Specialists of Michigan

Grand Rapids, MI United States
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The Retina Institute

Saint Louis, MO United States
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Retina Northwest, PC

Portland, OR United States
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Southeastern Retina Associates

Chattanooga, TN United States
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Austin Retina Associates

Austin, TX United States
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Retina Research Center

Austin, TX United States
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Spokane Eye Clinic

Spokane, WA United States
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Florida Retina Consultants

Lakeland, FL United States
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Retina Vitreous Center

Edmond, OK United States
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Oregon Retina, LLP

Eugene, OR United States
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Recruitment Status: Open


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