Liquid Biopsy Evaluation and Repository Development at Princess Margaret (LIBERATE)

  • End date
    Jul 5, 2023
  • participants needed
  • sponsor
    University Health Network, Toronto
Updated on 5 May 2022
cancer diagnosis
cancer treatment
primary cancer
tumor progression
solid tumor
Accepts healthy volunteers


The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the University Health Network's Princess Margaret Cancer Centre. Circulating cell-free nucleic acids (cfNA), including cell-free DNA (cfDNA) and cell-free RNA (cfRNA), are non-invasive, real-time biomarkers that can provide diagnostic and prognostic information before cancer diagnosis, during cancer treatment, and at disease progression. Cancer research scientists and clinicians at the Princess Margaret are interested in incorporating the collection of peripheral blood samples ("liquid biopsies") into research protocols as a means of non-invasively assessing tumor progression and response to treatment at multiple time points during a patient's course of disease.

Condition Cancer, Breast Cancer, Lung Cancer, Colon Cancer, Ovarian Cancer, Melanoma, Lymphoma, Leukemia, Mutation, Lynch Syndrome, Cowden Syndrome, BRCA1 Mutation, BRCA2 Mutation, Uterine Cancer, Myeloma, Kidney Cancer, Head and Neck Cancer, Meningioma
Clinical Study IdentifierNCT03702309
SponsorUniversity Health Network, Toronto
Last Modified on5 May 2022


Yes No Not Sure

Inclusion Criteria

Patients with either histological confirmation of a solid tumor or hematological malignancy, OR patients identified as high-risk for cancer (based on identified aberration in cancer predisposition gene or on hormonal and/or family history without known aberration)
Patient must be ≥ 18 years old
All patients must have signed and dated an informed consent form for this LIBERATE study
If patients are being co-consented for a separate primary research study listed in Appendix I, they must fulfill the eligibility criteria for that separate primary research study. If there is a discrepancy in the eligibility criteria between protocols, the separate primary research study's criteria take precedence

Exclusion Criteria

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