Study to Assess the Efficacy and Safety of LYS006 in Patients With Moderate to Severe Inflammatory Acne

  • STATUS
    Recruiting
  • End date
    Apr 29, 2022
  • participants needed
    56
  • sponsor
    Novartis Pharmaceuticals
Updated on 15 March 2021

Summary

The main purpose of this study is to assess preliminary efficacy and safety of LYS006 in patients with moderate to severe inflammatory acne and to determine if LYS006 has an adequate clinical profile for further clinical development.

Details
Condition Inflammatory Acne
Treatment Placebo, LYS006
Clinical Study IdentifierNCT03497897
SponsorNovartis Pharmaceuticals
Last Modified on15 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Male and female subjects aged 18 to 45 years of age inclusive, and otherwise in good health as determined by medical history, physical examination, vital signs, ECGs and laboratory tests at screening
Body weight between 50 and 120 kg, both inclusive, at screening
Patients with papulo-pustular acne vulgaris (inflammatory acne) presenting with 20 to 100 facial inflammatory lesions (papules, pustules and nodules) at baseline, no more than 2 facial inflammatory nodules or cysts at screening and baseline, and a minimun number of 10 non-inflammatory facial lesions (open and closed comedones)
Patients who are candidates for systemic treatment and for whom in the opinion of the investigator, an appropriate previous treatment with topical anti-acne medication failed, or was not well tolerated, or is not indicated (e.g., due to large body surface area affected, e.g., on the back)
Patients with Grade 3 (moderate) or Grade 4 (severe) IGA score confirmed by central reading of standardized image capture (Visia system) by an independent dermatologist at screening and by the investigator's clinical evaluation at baseline

Exclusion Criteria

Appropriate wash out periods are required for investigational drugs, any oral/systemic treatment for acne, systemic or lesional injected (for acne) corticosteroids or systemic immunomodulators, any systemic hormonal treatments, previous treatment with biologics, oral retinoids (in particular isotretinoin) and any topical anti-acne treatment
Previous surgical, physical (such as ThermaClear), light (including blue or UV light, photodynamic therapy or laser therapy within 4 weeks prior to baseline
Use of facial medium depth chemical peels (excluding home regimens) within 3 months prior to baseline
Any other forms of acne
Any severe, progressive or uncontrolled medical or psychiatric condition or other factors at randomization that in the judgment of the investigator prevents the patient from participating in the study
Active systemic infections (other than common cold) during the 2 weeks prior to baseline
History of immunodeficiency diseases, including a positive HIV (ELISA and Western blot) test result at screening
Chronic infection with Hepatitis B or Hepatitis C virus
Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive Human chorionic gonadotropin (HCG) laboratory test
Sexually active males or women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using basic methods of contraception during dosing of study treatment
Other protocol-defined inclusion/exclusion criteria may apply
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