Roll-over Study in Patients With Endogenous Cushing's Syndrome for LCI699

  • STATUS
    Recruiting
  • End date
    Sep 27, 2023
  • participants needed
    180
  • sponsor
    Novartis Pharmaceuticals
Updated on 26 January 2021
Investigator
Novartis Pharmaceuticals
Primary Contact
Novartis Investigative Site (8.7 mi away) Contact
+48 other location
lci699

Summary

The purpose of this study is the evaluation of long-term safety of osilodrostat in patients who have already received osilodrostat treatment in a previous Global Novartis-sponsored trial and who, based on investigators' judgement, will continue benefiting with its administration.

Details
Condition Cushing's Syndrome, cushing
Treatment Osilodrostat
Clinical Study IdentifierNCT03606408
SponsorNovartis Pharmaceuticals
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient is currently participating in a Global Novartis-sponsored study receiving osilodrostat for any type of endogenous CS and has fulfilled all their requirements in the parent study
Patient is currently benefiting from treatment with osilodrostat, as determined by the Investigator
Patient has demonstrated compliance, as assessed by the Investigator, with the parent study protocol requirements
Willingness and ability to comply with scheduled visits and treatment plans
Written informed consent obtained prior to enrolling into the roll-over study before evaluating the applicability of the subject's participating in the study. -- If consent cannot be expressed in writing, it must be formally documented and witnessed, ideally via an independent trusted witness

Exclusion Criteria

Patient has been permanently discontinued from osilodrostat study treatment in a parent Novartis-sponsor study
Patients who are receiving osilodrostat in combination with unapproved or experimental treatments for any type of endogenous CS
Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test. Pregnant or nursing (lactating) women
Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and for 1 week of study after stopping medication. Highly effective contraception methods include
Total abstinence (when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception
Female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or tubal ligation. at least six weeks before taking study treatment. In case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment
Male sterilization (at least 6 months prior to baseline). The vasectomized male partner should be the sole partner for that subject
Use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (IUD) or intrauterine system (IUS), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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