Alternative Neoadjuvant Chemotherapy in Resectable and Borderline Resectable Pancreatic Cancer

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    Benaroya Research Institute
Updated on 1 December 2022
platelet count
paclitaxel
cancer
fluorouracil
neutrophil count
gemcitabine
leucovorin
irinotecan
blood transfusion
biliary obstruction
resectable pancreatic cancer

Summary

Using alternative neoadjuvant gemcitabine-nab-paclitaxel and nal-IRI with 5-Fluorouracil (5FU) and folinic acid (Leucovorin) regimens of localized cancer, we hope to ensure exposure of the cancer to a broader array of potentially active agents. Also, potentially improves patient tolerance and minimizes significant drug toxicity that could impair delivery of all treatment elements. Furthermore, it may enable prediction of superior to inferior treatment outcomes at an earlier point in the disease progress.

Description

This research study is a Phase Ib clinical trial. It will assess the Safety, tolerability, and feasibility of gemcitabine-nab paclitaxel alternating with nal-IRI/5FU/leucovorin (NAPOLI) in de novo resectable and borderline resectable pancreatic cancer.

Subjects must have a newly diagnosed resectable or borderline resectable pancreatic ductal cancer and meet all inclusion/exclusion criteria.

Treatment consists of 4 week treatment cycles. Nab-paclitaxel and gemcitabine will be administered on days 1,8, and 15 with NAPOLI will be administered on days 1 and 15.

Details
Condition Pancreatic Adenocarcinoma
Treatment Gemcitabine, 5-FU, Leucovorin, Onivyde, nab paclitaxel
Clinical Study IdentifierNCT03703063
SponsorBenaroya Research Institute
Last Modified on1 December 2022

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