Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy

  • End date
    Jun 1, 2025
  • participants needed
  • sponsor
    Fudan University
Updated on 15 February 2022
liver metastasis
cancer chemotherapy


This study is a multi-center phase 3 trial to evaluate a treatment strategy for selecting patients who can benefit from the synchronous resection of primary pancreatic cancer and liver oligometastasis after induction chemotherapy. Half of participants who meet the entry criterion will receive surgical intervention, while the other half will continue to receive standard chemotherapy.

Condition Pancreatic Cancer, Liver Metastases, Surgery
Treatment Standard chemotherapy, Synchronous resection of primary pancreatic cancer and liver oligometastasis
Clinical Study IdentifierNCT03398291
SponsorFudan University
Last Modified on15 February 2022


Yes No Not Sure

Inclusion Criteria

Primary tumor and liver metastatic sites are both resectable
No new metastatic sites were observed
Abnormal serum tumor maker levels decreased by more than 50% after chemotherapy. In the serum tumor makers, carbohydrate antigen 19-9 (CA19-9) was always the first choice for evaluation and it should be below 500U/L after treatment. However, when the baseline CA19-9 was within the normal range, carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) were the alternative candidate indicators

Exclusion Criteria

Contraindication of operation
Clear my responses

How to participate?

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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