Drugs called checkpoint inhibitors help the immune system fight cancer. When the
effectiveness of these drugs wears off, it may be possible to renew their effectiveness by
combining it with a special type of radiation therapy called stereotactic body radiation
therapy (SBRT). SBRT is a commonly used type of radiation therapy that gives high dose
radiation with high precision to tumors in 1-5 treatments. Radiation therapy, such as SBRT
can also treat sites of metastases. The use of checkpoint inhibitors in combination with SBRT
has been suggested to improve the immune response against cancer but has not been tested in a
formal clinical trial. Up to three lesions can be treated with SBRT. This study only allows
checkpoint inhibitors that are already approved by the Federal Drug Agency (FDA) for the
treatment of your disease. All radiation therapy will be done on machines which are FDA
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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