Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

  • STATUS
    Recruiting
  • End date
    Dec 31, 2023
  • participants needed
    20
  • sponsor
    University of Louisville
Updated on 14 February 2022
pancreatic adenocarcinoma
gemcitabine
cancer chemotherapy
adenocarcinoma
folfirinox
advanced pancreatic adenocarcinoma

Summary

Compare the efficacy and tolerability of IRE in combination with either FOLFIRINOX or gemcitabine in patients with locally advanced pancreatic cancer.

Description

Phase II study in which all patients undergoing IRE for the treatment of locally advanced pancreatic carcinoma will receive either FOLFIRINOX or gemcitabine as peri-ablation treatment.

Details
Condition Pancreas Cancer
Treatment Gemcitabine, FOLFIRINOX, Irreversible electroporation (IRE)
Clinical Study IdentifierNCT03484299
SponsorUniversity of Louisville
Last Modified on14 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

greater than or equal to 18 years of age
diagnosed with stage III pancreatic cancer
tumor is measurable
GFR > mL/min/1.73m2
willing and able to comply with protocol requirements
AST/ALT >3 times upper limit of normal
stable surgical post-operative course as defined by operative surgeon

Exclusion Criteria

participating in another clinical trial for the treatment of cancer at the time of screening
pregnant or currently breast feeding
have a cardiac pacemaker or ICD implanted that cannot be deactivated during IRE procedure
have non-removable implants with metal parts within 1 cm of the target lesion
had a myocardial infarction within 3 months prior to enrollment
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