BLI NBI or White Light Colonoscopy for Proximal Colonic Adenoma

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    894
  • sponsor
    The University of Hong Kong
Updated on 8 April 2021
narrow band imaging

Summary

This is a prospective randomised trial comparing the proximal adenoma detection rate and miss rate by blue laser imaging (BLI), narrow band imaging or white light colonoscopy.

Description

Study population:

Consecutive adult patients, age 40 or above, undergoing outpatient colonoscopy in the Queen Mary Hospital are invited to participate in this prospective randomized study. Patients are excluded if they are unable to provide informed consent or have undergone previous colorectal resection, or have personal history of colorectal cancer, inflammatory bowel disease, familial adenomatous polyposis, Peutz-Jeghers syndrome, or other polyposis syndromes. Patients who are considered to be unsafe for polypectomy including patients with bleeding tendency and those with severe comorbid illnesses will be excluded. In addition, patients are excluded post-randomization if either the cecum could not be intubated for various reasons or Boston Bowel Preparation Scale (BBPS) score is <2.

Study design and randomization:

This is a prospective randomized crossover trial comparing the proximal adenoma detection rate and miss rate of BLI (ELUXEO endoscopic system) vs NBI (290 video system) vs WLI which is conducted in the Endoscopy Center of the Queen Mary Hospital of Hong Kong. Eligible patients are randomly allocated to four groups in a 1:1:1 ratio to undergo tandem colonoscopy of the proximal colon, defined as cecum to splenic flexure. The three groups are: (1) NBI follow by WLI; (2) BLI follow up WLI; (3) WLI follow by WLI. Randomization will be carried out by computer generated random sequences and stratified according to endoscopist's experiences (experienced versus fellows) and indications of colonoscopy (symptomatic vs screening/surveillance). All procedures are performed with high-definition endoscopes. The patients are blinded to the group assignment.

Details
Condition Colon Adenoma
Treatment Tandem colonoscopy
Clinical Study IdentifierNCT03696992
SponsorThe University of Hong Kong
Last Modified on8 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 40 or above
scheduled for colonoscopy

Exclusion Criteria

unable to provide informed consent
have undergone previous colorectal resection
personal history of colorectal cancer, inflammatory bowel disease, familial adenomatous polyposis, Peutz-Jeghers syndrome, or other polyposis syndromes
Patients who are considered to be unsafe for polypectomy including patients with bleeding tendency and those with severe comorbid illnesses
poor bowel preparation
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