The Association of G9a Protein and Clinical Outcome of Patients With Vulvar Cancer

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    Far Eastern Memorial Hospital
Updated on 17 September 2021

Summary

To assess the G9a expression in vulvar cancer

Description

Vulvar cancer can be treated with surgery, radiotherapy or chemoradiotherapy. Recurrence of vulvar cancer generally can be detected by imaging study. Currently, there is a paucity of sensitive marker to detect the recurrence of vulvar cancer. G9a is a recently identified protein with histone lysine methyltransferase activity. The role of histone methyltransferases in promoting tumorigenesis and progression of human cancers has been noted in some cancers, such as ovarian cancer, endometrial cancer and cervical cancer. The role of G9a protein in vulvar cancer remains obscure.

All female patients with vulvar cancer or vulvar intraepithelial neoplasm II /III who underwent surgery at Far Eastern Memorial Hospital from January 2003 will be included. All patients' clinical characteristerics including age, stage, pathologic finding, and follow-up data will be recorded from chart review.

The archived specimens will be used for immunohistochemical staining of G9a protein. Tumor size, local invasion, lymph node metastasis, and final disease stage will be determined. Correlation will be performed between G9a and clinical outcome of vulvar cancer.

Details
Condition Vulvar Cancer, G9a Protein, Vulvar Cancer, G9a Protein, Vulvar Cancer, G9a Protein, Vulvar Cancer, G9a Protein, Vulvar Cancer, G9a Protein, Vulvar Cancer, G9a Protein, Vulvar Cancer, G9a Protein, Vulvar Cancer, G9a Protein
Treatment G9a protein
Clinical Study IdentifierNCT03695809
SponsorFar Eastern Memorial Hospital
Last Modified on17 September 2021

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