Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients (TGC-fast)

  • STATUS
    Recruiting
  • End date
    Jan 28, 2026
  • participants needed
    9230
  • sponsor
    KU Leuven
Updated on 14 February 2022
insulin
critical illness
enteral nutrition

Summary

Critically ill patients usually develop hyperglycemia, which is associated with an increased risk of morbidity and mortality. Controversy exists on whether targeting normal blood glucose concentrations with insulin therapy, referred to as tight blood glucose control (TGC) improves outcome of these patients, as compared to tolerating hyperglycemia. It remains unknown whether TGC, when applied with optimal tools to avoid hypoglycemia, is beneficial in a context of withholding early parenteral nutrition. The TGC-fast study hypothesizes that TGC is beneficial in adult critically ill patients not receiving early parenteral nutrition, as compared to tolerating hyperglycemia.

Details
Condition Critical Illness, Hyperglycemia
Treatment insulin
Clinical Study IdentifierNCT03665207
SponsorKU Leuven
Last Modified on14 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patient (18 years or older) admitted to a participating intensive care unit (ICU)

Exclusion Criteria

Patients with a do not resuscitate (DNR) order at the time of ICU admission
Patients expected to die within 12 hours after ICU admission (= moribund patients)
Patients able to receive oral feeding (not critically ill)
Patients without arterial and without central venous line and without imminent need to place it as part of ICU management (not critically ill)
Patients previously included in the trial (when readmission is within 48 hours post ICU discharge, the trial intervention will be resumed)
Patients included in an IMP-RCT of which the PI indicates that co-inclusion is prohibited
Patients transferred from a non-participating ICU with a pre-admission ICU stay >7 days
Patients planned to receive parenteral nutrition during the first week in ICU
Patients suffering from diabetic ketoacidotic or hyperosmolar coma on ICU admission
Patients with inborn metabolic diseases
Patients with insulinoma
Patients known to be pregnant or lactating
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