Homoarginine Supplementation in Patients After Stroke (HiS)

  • End date
    Aug 9, 2023
  • participants needed
  • sponsor
    Universitätsklinikum Hamburg-Eppendorf
Updated on 14 February 2022


This study represents a follow-up of the previous study "Single and Multiple Doses of an Oral Formulation of L-Homoarginine in Healthy Human Subjects" (NCT02675660). This study will evaluate the applicability of an oral formulation of L-homoarginine to normalize homoarginine blood levels in patients with acute ischemic stroke.

Condition Deficiency; Diet
Treatment Placebo, 125 mg L-homoarginine
Clinical Study IdentifierNCT03692234
SponsorUniversitätsklinikum Hamburg-Eppendorf
Last Modified on14 February 2022


Yes No Not Sure

Inclusion Criteria

ischemic stroke (CT or MRI), high-risk transient ischemic attack (ABCD2-score >= 4) or acute central retinal artery occlusion
serum homoarginine </= 2.1 umol/L
signed informed consent

Exclusion Criteria

no acute stroke
serum homoarginine > 2.1 umol/L
heart failure (NYHA > 1)
chronic kidney disease (GFR <60 mL/min)
not competent
pregnancy, lactation
no or withdrawn signed informed consent
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