The Healthy Patterns Sleep Study
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- STATUS
- Recruiting
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- days left to enroll
- 51
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- participants needed
- 200
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- sponsor
- University of Pennsylvania
Summary
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia. We will use a randomized two-group parallel design of 200 people with dementia and their caregivers assigned to intervention or attention control groups.
Description
Over 5 million Americans have Alzheimer's disease or a related dementia, a progressive and fatal neurodegenerative condition, affecting close to 15 million family caregivers (CG). Circadian rhythm disorders (CRDs) occur in the majority of persons with dementia and include late afternoon/evening agitation (e.g. sundowning) and irregular sleep-wake rhythms such as daytime hypersomnia, frequent night awakenings, and poor sleep efficiency. CRDs can cause a specific cluster of neuropsychiatric symptoms that occur in over 60 percent of patients with dementia and are associated with increased morbidity and mortality and decreased quality of life. Regulating the circadian system via different types of activity have been shown to alter core clock processes that drive CRD symptoms and suggests that a combination of cognitive, physical, and sensory-based activities, delivered at strategic times, may be an effective mechanism to reduce neuropsychiatric symptoms, decrease sleep disruptions, and enhance quality of life for both the care receiver and the caregiver.
Specific components of this brief, one-month, eight sessions, home-based intervention include: 1) assessing PWD health/functional status and preferences/interests; 2) educating caregivers on environmental cues to promote activity and sleep; and 3) training of caregivers in using timed morning, afternoon, and evening activities based on circadian needs across the day.
Details
| Condition | Circadian Rhythm Sleep Disorder, Frontotemporal Dementia, Pick's Disease, Circadian Dysregulation, Vascular Dementia, Insomnia, Hypersomnia, Dementia, Memory impairment, Alzheimer's Disease, Sleep Disorders, Sleep Disorders (Pediatric), Mild Cognitive Impairment, Cognitive Impairment, Cognitive Dysfunction, Cognitive Decline, Neurocognitive Disorders, Neurocognitive Disorder, Cognitive Impairments, Mild Neurocognitive Disorder, Mental Deterioration, Memory Problems, sleep disorder, excessive sleepiness, impair memory, bad memory, disturbance of memory, neurocognitive disturbance, dementia, frontotemporal, alzheimer, dementia alzheimer's type |
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| Treatment | Attention-Control Condition, Timed Activity Intervention |
| Clinical Study Identifier | NCT03682185 |
| Sponsor | University of Pennsylvania |
| Last Modified on | 24 January 2021 |
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