Treatment of Intermittent Claudication by G-CSF-mobilized PB-MNC
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 40
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- sponsor
- Mahidol University
Summary
This study will investigate the efficacy of G-CSF mobilized mononuclear cell injection of patients with PAD who presented with intermittent claudication. Forty PAD patients who presented with intermittent claudication will be randomized into 2 groups. The control group will be treated by medication and walking exercise 3 times/ week. The experiment group will be injected G-CSF mobilized mononuclear cell ,medication and walking exercise 3 times/ week. Ankle brachial index(ABI), Toe brachial index (TBI) and transcutaneous oxygen measurement will be evaluated at the day of randomization, 1 , 3, 6 and 12 months
Description
This study will investigate the efficacy of G-CSF mobilized mononuclear cell injection of patients with PAD who presented with intermittent claudication. Forty PAD patients who presented with intermittent claudication will be randomized into 2 groups. The control group will be treated by medication and walking exercise 3 times/ week. The experiment group will be injected G-CSF mobilized mononuclear cell ,medication and walking exercise 3 times/ week. Ankle brachial index(ABI), Toe brachial index (TBI) and transcutaneous oxygen measurement will be evaluated at the day of randomization, 1 , 3, 6 and 12 months in the control group and day of randomization, 1 , 3, 6 and 12 months after injection of PB-MNC in the experiment group. Pain free walking distance will be evaluated at the day of randomization, 1 , 3, 6 and 12 months by pedometer.
Details
| Condition | Intermittent Claudication, PAD, Atherosclerotic Ischemic Disease |
|---|---|
| Treatment | PB-MNC therapy, No PB-MNC therapy |
| Clinical Study Identifier | NCT03683628 |
| Sponsor | Mahidol University |
| Last Modified on | 14 February 2022 |
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