Last updated on September 2018

ACEI/CCB Versus ACEI/DIU Combination Antihypertensive Therapy in Chinese Hypertensive Patients (ACvAD)


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Hypertension
  • Age: Between 18 - 65 Years
  • Gender: Male or Female

Inclusion Criteria:

  • over 18 years old; Patients who never taking antihypertensive drugs or stop taking antihypertensive drugs for more than 2 weeks, or receiving single-drug antihypertensive therapy, systolic blood pressure 140-179mmHg, or diastolic blood pressure 90-109mmHg, entering 4weeks observation period before enrollment. During the observation period, all patients take benazepril 10 mg daily, and office follow-up at 2 weeks and 4 weeks. If patients can take benazepril for 4 weeks continually, no adverse reaction, the mean systolic blood pressure of 6 office blood pressure readings is between 140 and 179mmHg, diastolic blood pressure 90-109mmHg in 2 office follow-ups, then can start group randomizing, using benazepril and switching to study medication; Regardless of whether the office blood pressure is in accordance with the enrollment conditions, monitoring family blood pressure for one week before randomizing, the blood pressure is measured twice every morning and night by an electronic sphygmomanometer; Agree to participate in the trial, and can insist follow-up.

Exclusion Criteria:

  • suspected or confirmed secondary hypertension; history of coronary heart disease, myocardial infarction, heart failure, stroke or dementia; other drugs that may affect blood pressure; liver function (ALT, AST, TBL) results Twice the upper limit, serum creatinine 1.5mg/dl (133mol/L), urine routine protein (+) or higher; blood potassium>5.5mmol/L or <3.5mmol/L; history of gout or male blood uric acid 420mol/L, female 360mol/L; elderly nursing home patients; or patients who are participating in other clinical trials.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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