Renin-angiotensin System Blockade Benefits in Clinical Evolution and Ventricular Remodeling After Transcatheter Aortic Valve Implantation (RASTAVI)

  • STATUS
    Recruiting
  • End date
    Feb 23, 2023
  • participants needed
    336
  • sponsor
    Hospital Clínico Universitario de Valladolid
Updated on 23 January 2021

Summary

The investigators aim to demonstrate that ramipril after transcatheter aortic valve implantation has benefits in terms of prognosis, cardiovascular events and ventricular remodeling (MRI).

Details
Condition ACE inhibitor, Transcatheter Aortic Valve Replacemen, angiotensin-converting enzyme inhibitor, angiotensin-converting enzyme inhibitors, ace inhibitors
Treatment ramipril
Clinical Study IdentifierNCT03201185
SponsorHospital Clínico Universitario de Valladolid
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Transcatheter aortic valve implantation due to severe aortic stenosis
Patients must give written informed consent

Exclusion Criteria

Severe mitral valvulopathy
Reduced left ventricular ejection fraction (LVEF < 40%) with myocardial infarction or dilated cardiomyopathy
Patients on an ACEI or an ARB the last 3 months
History of hypersensitivity or allergy to any of the study drugs, drugs of similar chemical classes, ACEIs, ARBs, or NEP inhibitors as well as known or suspected contraindications to the study drugs
Non-MR-conditional cardiac devices
Estimated GFR < 30 ml/min. GFR between 30 and 50 ml/min will not receive gadolinium during MRI
Systolic blood pressure < 100 mmHg or diastolic < 40 mmHg
Pregnant women
Participating in other investigational trial at the time of enrollment
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