Apixaban for Extended Anticoagulation (APIDULCIS) (APIDULCIS)

    Not Recruiting
  • End date
    Jan 27, 2023
  • participants needed
  • sponsor
    Arianna Anticoagulazione Foundation
Updated on 20 July 2022
venous thromboembolism
deep vein thrombosis
pulmonary embolism
anticoagulation therapy
apixaban 2.5 mg


The study aims at optimizing the long-term and extended management of patients with a first episode of venous thromboembolism (proximal deep vein thrombosis with or without pulmonary embolism) (VTE). Patients at high risk of recurrence (with altered D-dimer test), who had received anticoagulation (whatever the drug used) for 12-15 months after the first episode of thrombosis, will be treated with Apixaban 2,5 mg x 2 for 18 months as extended treatment. Patients at low risk, with normal D-dimer test, will stop anticoagulation definitely.


This prospective cohort study aims to assess the efficacy and safety of a management procedure to decide on giving or not an extended anticoagulation (administering apixaban 2 2.5 mg twice daily ) to outpatients with a single episode of proximal deep vein thrombosis of the lower limbs and/or pulmonary embolism who had received 12-15 months of anticoagulation (whatever the anticoagulant drug used). The study seeks to assess whether a management procedure involving D-dimer testing assessment can identify a subset of subjects at low risk of recurrence in whom an extended anticoagulation can be safely avoided.

Condition Venous Thromboembolism, Anticoagulants
Treatment Apixaban
Clinical Study IdentifierNCT03678506
SponsorArianna Anticoagulazione Foundation
Last Modified on20 July 2022

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