Impedancemetry in Patients Monitored for Pulmonary Hypertension (HPepic)

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  • participants needed
  • sponsor
    University Hospital, Toulouse
Updated on 15 June 2022


Monocentric cohort study, prospective, evaluating the variability of cardiac output measurement by resting and stress impedancemetry as a prognostic factor for Pulmonary Hypertension


Cardiac impedancemetry is a technique that allows an electrical representation of cardiac flows. To do this, 6 electrodes are applied to the thorax and a low intensity and high frequency electrical current is transmitted. The impedance is recorded and the variations of the impedance represent the changes in intra-thoracic volume and thus the volume of systolic ejection. This measurement can be done at rest but also during exercise during the walking test. A test of the NO / CO coupled transfer measurement is also performed.

The devices that will be used in this project are the Physio-Flow® system and Masterscreen NO / CO coupled transfer measurement device

Condition Pulmonary Hypertension
Treatment cardiac impedancemetry
Clinical Study IdentifierNCT03673774
SponsorUniversity Hospital, Toulouse
Last Modified on15 June 2022


Yes No Not Sure

Inclusion Criteria

Patient over 18 years and under 80 years
Patients who have been diagnosed with PAH (group 1 PH according to the Nice 2013 classification) or post-embolic pulmonary hypertension (group 4 PH) under medical treatment
HTP incident or prevalent less than 6 months
Patient coming for follow-up or emergency consultation or hospitalization with a clinical examination and a walking test
Patient affiliated to a health insurance scheme
Patient having signed informed consent

Exclusion Criteria

Subjects under juridical protections or tutelage measure
pregnant or lactating woman
pulmonary hypertension du to cardiac pathology, chronic respiratory disease, or uncertain determinism
pulmonary hypertension of group 4 treated surgically or endoscopically
pulmonary hypertension incident or prevail for 6 months or more
contraindication to impedancemetry
inability to perform a walking test
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