Last updated on July 2019

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors


Brief description of study

A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL LN-144 (Lifileucel)/LN-145 in combination with pembrolizumab. TIL as a single-therapy will be evaluated with LN-145 only.

Detailed Study Description

LN-144 (Lifileucel)/LN-145 is an adoptive cell transfer therapy that utilizes an autologous TIL manufacturing process for the treatment of patients with advanced unresectable or metastatic melanoma, advanced squamous cell carcinoma of the head and neck, and non-small cell lung cancer. The adoptive cell transfer therapy used in this study involves patients receiving a nonmyeloablative (NMA) lymphocyte depleting preparative regimen, followed by infusion of autologous TIL followed by the administration of a regimen of IL-2. Patients in Cohort 1A, Cohort 2A, and Cohort 3A will receive TIL plus pembrolizumab. Patients in Cohort 3B will receive TIL as a single therapy.

Clinical Study Identifier: NCT03645928

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University of Louisville

Louisville, KY United States
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