Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers (AURA Trial)

  • STATUS
    Recruiting
  • End date
    Dec 1, 2022
  • participants needed
    166
  • sponsor
    Jules Bordet Institute
Updated on 29 January 2021

Summary

Open-label, interventional, multi-centre, randomized phase II study. Cancer studied is non-metastatic muscle invasive bladder cancer (MIBC).

Avelumab administered every 2 weeks is used as neoadjuvant therapy in subjects with urothelial muscle invasive bladder cancers in combination with standard chemotherapy or alone.

Description

Open-label, interventional, multi-centre, randomized phase II study. Cancer studied is non-metastatic muscle invasive bladder cancer (MIBC) Patients (male or female) will receive avelumab every 2 weeks in combination with standard chemotherapy or alone. There are 2 cohorts of patients.

Cohort with patients cisplatin-ineligible will receive either avelumab alone or in combination with paclitaxel-gemcitabine chemotherapy.

Cohort with patients cisplatin-eligible will receive either methotrexate, vinblastine, doxorubicine and cisplatin in combination with avelumab or cisplatin, gemcitabine in combination with avelumab.

The estimated number of subjects to screen is 183 patients for an estimated number of 166 patients enrolled for 150 evaluable patients:

26 patients in the paclitaxel, gemcitabine in combination with avelumab arm (cisplatin-ineligible patients) 26 patients in avelumab alone arm (cisplatin-ineligible patients) 49 patients in cisplatin gemcitabine + avelumab arm (cisplatin-eligible patients) 49 patients in methotrexate, vinblastine, doxorubicine and cisplatin + avelumab arm (cisplatin-eligible patients)

AVELUMAB

Avelumab will be administered at a dose of 10 milligram per kilogram (mg/kg) 1-hour intravenous (iv) infusion once every 2 weeks. Dose reductions are not allowed.

Depending on the treatment arm, Avelumab will be given associated with chemotherapy or alone for a maximum of 4 administrations.

DD-MVAC:

DD-MVAC consists of Methotrexate 30 mg/m2 iv day 1, Vinblastine 3 mg/m2 iv day 2, Cisplatin 70 mg/m2 iv day 2 and Doxorubicin 30 mg/m2 iv day 2. Each cycle is given every 2 weeks for a maximum of 4 administrations. Pegfilgrastim 6 mg subcutaneous (SQ) 24-48 hours after completion of chemotherapy will be given.

Chemotherapy is associated with Avelumab 10 mg/kg iv given on day 2 every 2 weeks.

CG

CG consists of Gemcitabine 1000 mg/m2 iv in day 1 and day 8 and Cisplatin 70 mg/m2 iv in day

  1. Each cycle is given every 3 weeks for a maximum of 4 administrations. Pegfilgrastim 6 mg subcutaneous (SQ) 24-48 hours after completion of chemotherapy will be given.

Chemotherapy is associated with Avelumab 10 mg/kg iv given on day 1 every 2 weeks.

PG

PG consists of Paclitaxel 80 mg/m2 iv in day 1 and day 15 and Gemcitabine 1000 mg/m2 iv in day 1 and day 15. Each cycle is repeated every 4 weeks for a maximum of 4 administrations.

Chemotherapy is associated with Avelumab 10 mg/kg i.v. given every on day 1 every 2 weeks.

For patients receiving neoadjuvant chemotherapy treatment, the surgery (cystectomy or nephroureterectomy associated to lymphadenectomy) will be performed within 3-6 weeks after the last administration of neoadjuvant chemotherapy treatment.

For patients receiving avelumab alone, the surgery will be performed 2 weeks (+7 days) after the last administration of avelumab.

Any delay in surgery (> 6 weeks after the last chemotherapy administration or >3 weeks after the last administration of avelumab alone) for any reason, needs to be discussed with the PI/Sponsor.

For all patients, neoadjuvant treatment will be stopped if there is evidence of progression of disease (by RECIST 1.1 or investigator's decision) or unacceptable toxicity according to the investigator. In this situation, the investigator will decide if it is needed to proceed directly with the surgery.

The end of study will be declared when all the following criteria will have been met:

  • The study ends after last visit of the last patient remaining in the study.
  • The trial is mature for the analysis of the endpoints as defined in the protocol, if the trial reaches its endpoints.
  • The database has been fully cleaned and frozen for all analyses.

Details
Condition Non-metastatic Muscle Invasive Bladder Cancer, Non-metastatic Muscle Invasive Bladder Cancer, Non-metastatic Muscle Invasive Bladder Cancer, Non-metastatic Muscle Invasive Bladder Cancer, Non-metastatic Muscle Invasive Bladder Cancer, Non-metastatic Muscle Invasive Bladder Cancer, Non-metastatic Muscle Invasive Bladder Cancer, Non-metastatic Muscle Invasive Bladder Cancer
Treatment Avelumab, Cystectomy, CG, CG, DD-MVAC, PG, PG
Clinical Study IdentifierNCT03674424
SponsorJules Bordet Institute
Last Modified on29 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Non-metastatic Muscle Invasive Bladder Cancer?
Do you have any of these conditions: Do you have Non-metastatic Muscle Invasive Bladder Cancer??
Age 18 years old
Must have histologically confirmed muscle invasive urothelial carcinoma (transitional cell carcinoma) or urothelial carcinoma with mixed histology of the bladder, renal pelvis or ureters. Stage permitted: T2, T3 or T4a. T stage is based on the standard of care transurethral resection of the bladder tumour (TURBT) sample
Patients may have nodal disease (Nx, N0, N1 or N2) at imagery but there must be no evidence of distant metastases (M0)
Performance status 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
Be a medically appropriate candidate for surgery as determined by an attending urologist
Adequate bone marrow function as defined below
Absolute neutrophil count 1500/L or 1.5x109/L
Hemoglobin 9 g/dL
Platelets 100000/L or 100x109/L 7)
Adequate liver function as defined below
Serum total bilirubin 1.5 x ULN. In case of known Gilbert's syndrome < 3xUNL is allowed
AST (SGOT)/ALT (SGPT) 2.5 x ULN
Serum pregnancy test (for subjects of childbearing potential) negative within 7 days prior to study treatment administration
Women of childbearing potential must agree to use one highly effective method of contraception prior study entry, during the course of the study and up to 6 months after the last administration of study treatment. Men with childbearing potential partner must agree to use condom during the course of this study and up to 6 months after the last administration of the study treatment
Completion of all necessary screening procedures within 28 days prior to treatment
Availability of biological material for screening and/or translational research activities
Signed Informed Consent form (ICF) obtained prior to any study related procedure
Cisplatin-eligible cohort specific criteria
\. Glomerular filtration rate (GFR) or Creatinine Clearance 60 mL/min
according to the Cockcroft-Gault formula (or local institutional standard
method) and
\. Peripheral neuropathy grade 1 and
\. Hearing impaired grade 1 and
\. Adequate cardiac function (Left Ventricular Ejection Fraction LVEF 55%)
by MUGA (Multiple-Gated Acquisition) scan or echocardiography
Cisplatin ineligible cohort specific criteria (if any of the following
criteria)
\. Glomerular filtration rate (GFR) or Creatinine Clearance 30mL/min
according to the Cockcroft-Gault formula (or local institutional standard
method) or
\. Peripheral neuropathy grade 2 or
\. Hearing impaired grade 2
Inclusion criterion specific for France
\. Patients must be affiliated to a social security system

Exclusion Criteria

Subjects meeting one of the following criteria are not eligible for this
study
Metastatic disease (M1)
Has had prior systemic chemotherapy, targeted small molecule therapy, or radiation therapy for urothelial carcinoma
Prior treatment with drug specifically targeting T-cell co-stimulation or checkpoint pathways
Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. Systemic corticosteroids at physiologic doses 10 mg/day of prednisone or equivalent; c. Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Has an active autoimmune disease that might deteriorate when receiving an immunostimulatory agent. Patients with diabetes type I, vitiligo, psoriasis, or hypoor hyperthyroid diseases not requiring immunosuppressive treatment are eligible
Has had a prior organ transplantation including allogenic stem-cell transplantation
Has an active infection requiring systemic therapy
Has a known history of Human Immunodeficiency Virus (HIV) or known acquired immunodeficiency syndrome
Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA is detected)
Has received vaccination within 4 weeks of the first dose of avelumab and while on trials is prohibited except for administration of inactivated vaccines such as influenza vaccine
Is currently participating in or has participated in a study of an investigational agent or using an investigational device within 28 days prior to study registration
History of prior invasive malignancy within 2 years (exception of adequately treated carcinoma in situ of the cervix, basal or squamous cell skin cancer, localised prostate cancer or ductal carcinoma in situ)
Known prior severe hypersensitivity to investigational product or any component in its formulations, including known severe hypersensitivity reactions to monoclonal antibodies (NCI CTCAE v4.03 Grade 3)
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (< 6 months prior to enrolment), myocardial infarction (< 6 months prior to enrolment), unstable angina, congestive heart failure ( New York Heart Association Classification Class II), or serious cardiac arrhythmia requiring medication
Pregnant and/or lactating women
Subject with a significant medical, neuro-psychiatric, or surgical condition, currently uncontrolled by treatment, which, in the principal investigator's opinion, may interfere with completion of the study
Persisting toxicity related to prior therapy (NCI CTCAE v. 4.03 Grade >1); however, alopecia, sensory neuropathy Grade 2, or other Grade 2 not constituting a safety risk based on investigator's judgment are acceptable
Other severe acute chronic medical conditions including immune colitis, inflammatory bowel disease, immune pneumonitis, pulmonary fibrosis or psychiatric conditions including recent (within the past year) or active suicidal ideation or behaviour; or laboratory abnormalities that may increase the risk associated with the study participation or study treatment administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study
Exclusion criterion specific for France
\. Vulnerable persons according to the article L.1121-6 of the CSP, adults
who are the subject of a measure of legal protection or unable to express
their consent according to article L.1121-8 of the CSP
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