Last updated on August 2019

National Cardiogenic Shock Initiative

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Myocardial Infarction | Cardiogenic shock | Acute Myocardial Infarction | NSTEMI - Non-ST Segment Elevation MI | STEMI - ST Elevation Myocardial Infarction
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Registry Inclusion Criteria:

  1. Symptoms of acute myocardial infarction (AMI) with ECG and/or biomarker evidence of S-T elevation myocardial infarction (STEMI) or non-S-T elevation myocardial infarction (NSTEMI)
  2. Cardiogenic shock is defined as the presence of at least two of the following:
  3. Hypotension (systolic blood pressure 90 mm Hg, or inotropes/vasopressors to maintain systolic blood pressure 90 mmHg)
  4. Signs of end organ hypoperfusion (cool extremities, oliguria or anuria, or elevated lactate levels)
  5. Hemodynamic criteria represented by a cardiac index of <2.2 L/min/m2 or a cardiac power output 0.6 watts.
  6. Patient is supported with an Impella
  7. Patient undergoes PCI

Registry Exclusion Criteria:

  1. Evidence of Anoxic Brain Injury
  2. Unwitnessed out of hospital cardiac arrest or any cardiac arrest in which return of spontaneous circulation (ROSC) is not achieved within 30 minutes
  3. IABP placed prior to Impella
  4. Septic, anaphylactic, hemorrhagic, and neurologic causes of shock
  5. Non-ischemic causes of shock/hypotension (pulmonary embolism, pneumothorax, myocarditis, tamponade, etc.)
  6. Active bleeding for which mechanical circulatory support is contraindicated
  7. Recent major surgery for which mechanical circulatory support is contraindicated
  8. Mechanical complications of AMI (acute ventricular septal defect (VSD) or acute papillary muscle rupture)
  9. Known left ventricular thrombus for which mechanical circulatory support is contraindicated
  10. Mechanical aortic prosthetic valve
  11. Contraindication to intravenous systemic anticoagulation

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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