Losartan and Nivolumab in Combination With FOLFIRINOX and SBRT in Localized Pancreatic Cancer

    Not Recruiting
  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    Massachusetts General Hospital
Updated on 14 September 2022
neutrophil count
pancreatic adenocarcinoma
stereotactic body radiation therapy
cancer chemotherapy
pancreatic neoplasm


This research study is studying a combination of interventions as a possible treatment for pancreatic tumor.

The interventions involved in this study are:

  • FOLFIRINOX which is made up of 4 different drugs:
  • 5-Fluorouracil (5-FU)
  • Oxaliplatin
  • Irinotecan
  • Leucovorin
  • Losartan
  • Nivolumab
  • Radiation Therapy
  • Surgery


This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. "Investigational" means that the intervention is being studied.

The FDA (the U.S. Food and Drug Administration) has approved FOLFIRINOX as a treatment option for this disease.

The FDA has not approved losartan or nivolumab for this specific disease but they have been approved for other uses.

FOLFIRINOX is a combination of 4 chemotherapy agents that may help shrink your tumor before surgery. Losartan is a drug that is used to lower blood pressure. Nivolumab is an antibody (a cell that attaches to other cells to fight off infection) that may cause programmed cell death of cancer cells. Radiation therapy is believed to increase the likelihood of response of immunotherapy (the prevention/treatment of a disease through an immune response).

Condition Pancreatic Cancer
Treatment SBRT, Surgery, Nivolumab, losartan, FOLFIRINOX
Clinical Study IdentifierNCT03563248
SponsorMassachusetts General Hospital
Last Modified on14 September 2022

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note