Losartan and Nivolumab in Combination With FOLFIRINOX and SBRT in Localized Pancreatic Cancer

  • STATUS
    Not Recruiting
  • End date
    Dec 31, 2025
  • participants needed
    160
  • sponsor
    Massachusetts General Hospital
Updated on 14 September 2022
fluorouracil
potassium
metastasis
oxaliplatin
neutrophil count
pancreatic adenocarcinoma
leucovorin
irinotecan
stereotactic body radiation therapy
nivolumab
cancer chemotherapy
adenocarcinoma
celiac
folfirinox
pancreatic neoplasm

Summary

This research study is studying a combination of interventions as a possible treatment for pancreatic tumor.

The interventions involved in this study are:

  • FOLFIRINOX which is made up of 4 different drugs:
  • 5-Fluorouracil (5-FU)
  • Oxaliplatin
  • Irinotecan
  • Leucovorin
  • Losartan
  • Nivolumab
  • Radiation Therapy
  • Surgery

Description

This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. "Investigational" means that the intervention is being studied.

The FDA (the U.S. Food and Drug Administration) has approved FOLFIRINOX as a treatment option for this disease.

The FDA has not approved losartan or nivolumab for this specific disease but they have been approved for other uses.

FOLFIRINOX is a combination of 4 chemotherapy agents that may help shrink your tumor before surgery. Losartan is a drug that is used to lower blood pressure. Nivolumab is an antibody (a cell that attaches to other cells to fight off infection) that may cause programmed cell death of cancer cells. Radiation therapy is believed to increase the likelihood of response of immunotherapy (the prevention/treatment of a disease through an immune response).

Details
Condition Pancreatic Cancer
Treatment SBRT, Surgery, Nivolumab, losartan, FOLFIRINOX
Clinical Study IdentifierNCT03563248
SponsorMassachusetts General Hospital
Last Modified on14 September 2022

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