Last updated on February 2018

Folinic Acid in Children With Autism Spectrum Disorders

Brief description of study

The investigator planned to study the efficiency of folinic acid treatment on autistic symptoms in children suffering from autism spectrum disorder.

Detailed Study Description

The aim of this study is to realise a pilot study in France in order to evaluate the efficiency of folinic acid in treatment of autism spectrum disorder and get first estimations about prevalence of auto antibodies anti-FR in France.

The study is a randomized controlled trial monocentric,evaluating folinic acid 10mg per day versus placebo, in single-blind during 12 weeks.

Primary objective : The primary objective is to evaluate the efficiency of folinic acid (calcium folinate) 5mg twice a day during 12 weeks on reduction of autistic troubles, particularly on communication and social interaction

Secondary objective :

  • Evaluate the efficiency of folinic acid on reduction of autistic symptoms perceived by parents
  • Evaluate the constancy of auto antibodies anti-FR rates

Clinical Study Identifier: NCT02551380

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CHU Nancy-Hopital Brabois Enfants
Vandoeuvre les Nancy, France
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Recruitment Status: Open

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