Fresh Vs Frozen Surgical Sperm in IVF

  • STATUS
    Recruiting
  • End date
    Feb 23, 2022
  • participants needed
    65
  • sponsor
    Reproductive Medicine Associates of New Jersey
Updated on 23 January 2021
follicle stimulating hormone
antral
anti-mullerian hormone
embryo transfer
intracytoplasmic sperm injection
antral follicle count
single embryo transfers

Summary

The primary objective of this study is to determine if the use of frozen surgical testicular sperm specimens for ICSI lead to different IVF outcomes when compared with the use of fresh surgical testicular sperm for ICSI.

Description

The study seeks to isolate the effect of slow freezing and thawing of surgical sperm specimens on fertilization and embryo blastulation rates by utilizing a randomized controlled split cohort protocol including men with obstructive azoospermia undergoing surgical sperm retrieval and good-prognosis female patients.

Details
Condition Female Genital Diseases, Infertility, Gynecological Infections, sterility, unable to conceive
Treatment Slow Freezing and Thawing
Clinical Study IdentifierNCT03361982
SponsorReproductive Medicine Associates of New Jersey
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Gender: Male or Female
Do you have Infertility?
Do you have any of these conditions: unable to conceive or Female Genital Diseases or sterility or Gynecological Infections or Infertility?
Females age < 42 with an indication for IVF
Females with lowest AMH level 1.2 ng/mL or higher
Females with FSH < 13 mIU/mL
Sperm obtained via Surgical retrieval (any type) for IVF only
Use of comprehensive chromosome screening (CCS) to screen embryos for aneuploidy
BMI < 35
Baseline antral follicle count of > 8
Single embryo transfers only

Exclusion Criteria

Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study
Contraindication to IVF
Clinical indication for preimplantation genetic diagnosis (PGD) (i.e., screening for single gene disorder, chromosomal translocation, or any other disorders requiring detailed embryo genetic analysis)
Fewer than 4 mature oocytes retrieved (will not randomize)
Male partner with non-obstructive azoospermia
Male partner with any Karyotype other than 46,XY
Male partner with history of spinal cord injury
Male partner with Kallman's syndrome
History of chronic oligomenorrhea
History of hydrosalpinges or adnexal mass
History of endometrial insufficiency (max endometrial thickness < 7mm)
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

Phone Email

0/250
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note