Fresh Vs Frozen Surgical Sperm in IVF

  • End date
    Feb 23, 2022
  • participants needed
  • sponsor
    Reproductive Medicine Associates of New Jersey
Updated on 23 January 2021
follicle stimulating hormone
anti-mullerian hormone
embryo transfer
intracytoplasmic sperm injection
antral follicle count
single embryo transfers


The primary objective of this study is to determine if the use of frozen surgical testicular sperm specimens for ICSI lead to different IVF outcomes when compared with the use of fresh surgical testicular sperm for ICSI.


The study seeks to isolate the effect of slow freezing and thawing of surgical sperm specimens on fertilization and embryo blastulation rates by utilizing a randomized controlled split cohort protocol including men with obstructive azoospermia undergoing surgical sperm retrieval and good-prognosis female patients.

Condition Female Genital Diseases, Infertility, Gynecological Infections, sterility, unable to conceive
Treatment Slow Freezing and Thawing
Clinical Study IdentifierNCT03361982
SponsorReproductive Medicine Associates of New Jersey
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

Gender: Male or Female
Do you have Infertility?
Do you have any of these conditions: unable to conceive or Female Genital Diseases or sterility or Gynecological Infections or Infertility?
Females age < 42 with an indication for IVF
Females with lowest AMH level 1.2 ng/mL or higher
Females with FSH < 13 mIU/mL
Sperm obtained via Surgical retrieval (any type) for IVF only
Use of comprehensive chromosome screening (CCS) to screen embryos for aneuploidy
BMI < 35
Baseline antral follicle count of > 8
Single embryo transfers only

Exclusion Criteria

Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study
Contraindication to IVF
Clinical indication for preimplantation genetic diagnosis (PGD) (i.e., screening for single gene disorder, chromosomal translocation, or any other disorders requiring detailed embryo genetic analysis)
Fewer than 4 mature oocytes retrieved (will not randomize)
Male partner with non-obstructive azoospermia
Male partner with any Karyotype other than 46,XY
Male partner with history of spinal cord injury
Male partner with Kallman's syndrome
History of chronic oligomenorrhea
History of hydrosalpinges or adnexal mass
History of endometrial insufficiency (max endometrial thickness < 7mm)
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